For more information about the diet, please visit HistamineReducingDiet.com.
Symptom Management & Mast Cell Degranulation Triggers
It is extremely important for patients to respect their illness, learn their individual symptoms and try to identify what triggers each symptom for them.
Mast cell disorders are neoplastic disorders, which means the mast cells multiply continuously over the patient's lifetime. As with cancer cells, mast cells do not die,
disappear, or cease to function, on their own. Unlike cancer cells, mast cells are normally good cells. But it's a case of having too much of a good thing.
That can be just as damaging and life threatening as a malignancy.
Every time a patient encounters a trigger, they risk their mast cells mutliplying in number. Too many mast cells will increase their suffering
and eventually could potentially shorten their life span. So it is vitally important for patients to avoid triggering mast cell degranulation
to both lessen their suffering, and preserve their quality and length of life.
In addition, when mast cells degranulate, they dump a host of chemicals at once, triggering the patient's symptoms.
These chemicals include histamine, heparin, prostaglandins, neutral proteases, acid hydrolases, chemokines and cytokines, just to name a few.1
Different symptoms may each have a unique trigger, or a cluster of triggers, per patient. In the exhaustive list
of potential triggers, as with symptoms, some patients will have only a few triggers, some will have many triggers, some may unfortunately be
susceptible to nearly all the known triggers. The best way to identify and remember
their symptoms and triggers is for patients to maintain an ongoing record, updating it as needed. Download this Activity Log form to help you
record your daily health.
When the symptoms occur, it is common for patients to have difficulty thinking clearly, which restricts their ability to help themselves.
Mast cells are in every organ including the brain. When symptoms occur, many patients experience problems speaking or articulating their needs,
or even understanding what exactly is happening to them and what they need to do about it.
A personal symptom and trigger record will help the patient as well as caregivers, physicians and emergency medical professionals.
Visit our Patients section of this website for information on how to live with these disorders.
We have listed 58 signs and symptoms of these disorders already.
Listed below are the medically researched and identified triggers which cause symptom and disease progression. We recommend sharing these lists
of triggers with every physician (family and all specialists), dentist, optometrist/opthalmologist, nuclear medicine and x-ray technicians
(BEFORE undergoing any tests), paramedics and other medical or natural health professionals you consult.
Download our food guideline, The Histamine & Tyramine Restricted Diet.
Nonimmunologic Histamine Releasers - and - Other Degranulation Triggers2
- Compound 48/80
- Calcium ionophore A23187
- Bacterial Toxins
- Snake venoms
- Biologic polypeptides
- Ascaris species
- Portuguese man-of-war
- Spines & hairs of Caterpillars
- Shellfish, Any fish not fresh
- Egg Whites
- Nuts (peanuts, walnuts etc.)
- **Download our diet guideline.
- Chemicals & Drugs
- Opiates (Codeine,Morphine,Percocet/Oxy etc)
- NSAIDs (Non-steroidal anti-inflammatories: Advil,Motrin,etc)
- Polymyxin B sulfate
- Colistin sulfate
- Thiamine hydrochloride
- Trimethaphan and Trimetaphan
- Tubocurarine chloride
- Quinine sulfate
- Dipyridamole (Persantine)
- Iodine based radiographic dyes
- Scopolamine hydrochloride
- Gallamine triethiodide
- Neuromuscular blocking agents (all):eg.,
- Gallamine triethiodide
- Dextromethorphan (cough suppressant)
- Stilbamadine isethionate
- Chlortetracycline bisulfate
- Hydralazine hydrochloride
- Tolazoline hydrochloride
- Cinnamic acid
- Benzoic acid
- Sodium benzoate
- Fungal infection drugs
- Local anesthestics: lidocaine,etc.(any amino amide-type)
- Physical Agents
- Dermatographia (Darier's Sign)
- Cholinergic agents
- Exercise, hot baths/showers, fever, occlusive dressings,
eating spicy foods, emotional stress
- Solar light waves
- Insect bites (Wasp, Hornet, Bee, Mosquito)
- Scents/Odors, Smoke (wood burning, cigarette, marijuana)
- Perfume, Man-made materials, Scented products, Chemicals
- Foods (**Download our diet guideline.)
- High in Histamine or Tyramine, Gluten, Soy, Salicylates
- Cosmetics/Creams containing salicylates
- Preservatives, Additives, Dyes, Artificial flavours/colouring
- Internal diseases
Contact Agent Triggers of Skin Reactions2
- Acrylic monomer
- Animal Dander
- Cat and Dog Saliva
- Benzoyl peroxide
- Castor beans
- Cetyl alcohol
- Cobalt chloride
- Cod liver oil
- Estrogenic creams
- Exotic woods
- Hair sprays
- Horse serum
- Nail polish
- Phenylmercuric propionate
- Platinum salts
- Sodium sulfide
- Stearyl alcohol
- Sulfur dioxide
- Taliphatic polyamide
- Tetanus antitoxin
- Sever,A; Sibbald,G; D'Arville,C: Thousand Faces of Mastocytosis: Mistaken Medical Diagnoses, Patient Suffering & Gender Implications University of Toronto Press: 7. 2009.
- Burrall,B; Halpern,G.M; Huntley,A: Medical Progress: Chronic Urticaria West J Med March 1990;152:268-276