|Signs and symptoms of Mastocytosis and Mast Cell Activation Syndrome are many and variable per patient. Idiopathic Anaphylaxis patients experience
many of the same symptoms, have few if any signs or indicators to explain their illness, but their dominant symptom of anaphylaxis persists.
The signs (eg.skin spots, unusual lab test results, etc.) appear due to an over-abundance of mast cells either limited to
the skin or internally, or both. The symptoms occur when mast cells are triggered to degranulate.
Mast cell degranulation is a normal response of the immune system
trying to protect the body. However, these disorders trigger mast cell activation (ie. degranulation) with or without apparent or valid trigger. Things such as foods and drinks,
extreme temperatures in water or air, emotional and physical stress - these are only a few examples - can trigger mast cell degranulation for these patients.
If the patient has both an over-abundance of mast cells, in addition to having excessively active mast cells (ie. degranulating when they should not), then the symptoms and illness become more severe, prolonged and life threatening.
Some patients experience only a few symptoms,
some experience many, some have all of them at various times or persistently. There is no way to fully predict what each patient will experience.
Initially, only a few signs and symptoms may be present. Especially if diagnosis takes several years, the signs and symptoms
escalate in type, severity, frequency and persistence, eventually leading to permanent disability or death. Listed below are 58 signs and symptoms reported to us by patients
consistently over the past 10 years.
skin lesions or sores
skin rash, spots, redness
flushing & severe sweating
joint, bone pain
tachycardia (racing heartrate)
eyes tearing/dry, eye pain
persistent body/tissue pain
episodes of low body temperature
unexplained Vitamin B12 deficiency
difficult menses (females)
numbness & tingling
in face and extremities
skin feels on fire
sudden drops in blood pressure
unexplained weight loss
swelling & inflammation
odd reactions to insect stings
decreased bone density
shortness of breath
temperature (hot/cold) sensitivity
difficulty with foods, drinks
gastrointestinal pain, bloating
unexplained medication reactions
enlarged lymph nodes
unexplained bruising, bleeding
intermittent tinnitus or hearing problems