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Patients with these disorders may develop additional ailments which need to be managed along with their primary disease. In recent years, medical research has linked mast cells as contributing factors impacting Diabetes 1,2,3, Arthritis 3,4, Cerebral Aneurysms5, and types of Cancer 6 beyond those known to be associated with Mastocytosis.

Below is our list of additional illnesses suffered by mastocytosis, MCAS and IA patients reporting to us in Canada. It is unknown why some mastocytosis and mast cell activation syndrome patients develop these complications while others do not. However, the incidences of additional ailments are rising, seeming to multiply the longer the patient lives with these mast cell disorders.

Physicians need to be aware of these secondary health conditions. If patients report symptoms which relate to other conditions, further testing should be considered. This list is likely incomplete. As mast cells are an immune system cell, patients with mast cell disorders may be at risk for an endless variety of health complications.
  • Osteopenia/Osteoporosis
  • Angioedema
  • Interstitial Cystitis (Bladder pain syndrome)
  • Uveitis (Iritis)
  • Arthritis & specific rare diseases of Arthritis
    • Rheumatoid arthritis
    • Sjogren's
    • Raynaud's
    • Osteoarthritis
    • Ehlers-Danlos
    • Fibromyalgia
    • Lupus
  • Chronic Fatigue Syndrome
  • Anaphylaxis
  • Cystic Acne
  • Vertigo
  • Diabetes
  • Postural tachycardia syndrome (POTS)
  • Dysautonomia
  • Hypertension
  • Discoid lupus erythematosus (DLE)
  • Multiple Chemical Sensitivity
  • Periodontal disease
  • Charcot-Marie Tooth
  • Macular Degeneration
  • Multiple Sclerosis
  • Addison's Disease
  • Neuropathy
  • Restless Leg Syndrome
  • Hypercalcemia
  • Anemia
  • Eosinophilic esophagitis
  • Mitral valve prolapse
  • Vascular dementia
  • Cerebral tumour
  • Pituitary tumour
  1. Geoffrey,R; Jia,S; Kwitek,A.E; Woodliff,J; Ghosh,S; Lernmark,A; Wang,X; Hessner,M.J:   Evidence of a Functional Role for Mast Cells in the Development of Type 1 Diabetes Mellitus in the BioBreeding Rat The Journal of Immunology, vol. 177 no. 10 7275-7286 November 15, 2006. [Abstract]
  2. Liu,J; Divoux,A; Sun,J; Zhang,J; Clement,K; Glickman,J.N; Sukhova,G.K; Wolters,P.J; Du,J; Gorgun,C.Z; Doria,A; Libby,P; Blumberg,R.S; Kahn,B.B; Hotamisligil,G.S; Shi,G-P:  Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice Nature Medicine 15, 940 - 945 26 July 2009.[Open Access]
  3. Richards,B:  Immunometabolism: The New Frontier Expertclick August, 2009.[Open Access]
  4. Bland,J:  Medicine's new direction Chiropractic News March 2008. [Open Access]
  5. Ishibashi,R; Aoki,T; Nishimura,M; Hashimoto,N; Miyamoto. S:  Contribution of mast cells to cerebral aneurysm formation  Current Neurovascular Research,Japan.7(2):113-24. 2010 May [Abstract]
  6. deGier,V.:  Specific immune cells play an essential role in tumor growth University of California, San Francisco Research News September 30, 2007. [Open Access]

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